Givaudan presents hyaluronic acid and amino acid complex to address skin aging pathway
Last update on Mar 30, 2026
Givaudan Active Beauty presents PrimalHyal™ NeuroYouth, an innovative complex based on low molecular weight hyaluronic acid and amino acids designed to address a recently identified skin aging pathway defined by Givaudan Active Beauty as ‘Neuro Skin Aging’. By restoring nerve fiber function and neuronal communication, PrimalHyal™ NeuroYouth opens up a new frontier in skin health and well-aging, where sensory perception becomes a new dimension of youthful-looking skin.
Interested in Givaudan’s ingredients? Explore their profile now!
Apparent skin age reduced by over 5 years
Beyond its protective barrier function, the skin is a living sensory network. With age, the skin’s nerve fibers become fewer, shorter, and less functional, leading to decreased sensory perception, but also to impaired cellular communication and accelerated skin aging. This process has been highlighted by Givaudan Active Beauty’s research and recognized among the IFSCC 2025 scientific contributions.
Seeking anti-aging agents from Givaudan? View all grades!
To address this new longevity pathway, Givaudan Active Beauty has leveraged the skin’s natural affinity for very low molecular weight hyaluronic acid as a vector to optimize the delivery of selected amino acids within the skin. Inspired by microneedling delivery concepts described in cosmetic and pharmaceutical literatures, PrimalHyal™ NeuroYouth is a unique hyaluronic acid-base amino-acid complex designed to enhance skin bioavailability and the biological relevance of the amino acids.
Clinical studies conducted on more than 120 volunteers demonstrate that PrimalHyal™ NeuroYouth delivers visible and measurable anti-ageing benefits, including:
- Apparent skin age reduced by over 5 years
- Visible reduction in wrinkles and fine lines
- Improvement in dermal tension and skin firmness
- Touch perception restored by up to 30 years
- Perceivable improvement of pleasant sensations
Anti-aging agents: How to select the right grade for cosmetics? >> Decode here >>
PrimalHyal™ NeuroYouth reverses the neuro-aging pathway, enabling neuronal growth and density-related parameters (with a +28% increase in nerve fiber count and a +29% increase in their length), enhancing neuronal communication pathways through NGF-like activity, reactivating neuronal mitochondria energetic efficiency. By supporting the skin’s neuro-sensory environment and helping to preserve skin homeostasis, PrimalHyal™ NeuroYouth contributes to stronger-looking, healthier, and more comfortable skin, while enhancing the perceived capacity of the skin to sense and interact with its environment.
“Beyond aesthetics, PrimalHyal™ NeuroYouth redefines skin aging from a skin health perspective. By addressing ‘Neuro Skin Aging’, it offers new perspectives for the positioning of silver age, pre-juvenation and skin resilience concepts, where neurological health becomes a key pillar of youthful skin,” said Romain Reynaud, R&D director at Givaudan Active Beauty.
To learn more about the new ingredient and its inspirational concept, S3D® ReSense, Delight Body Lotion, and S3D® ReSense, Youth-Awakening Serum, the company invites attendees to visit us on 14-16 April 2026 at booth #3F110, 3F130 at in-cosmetics Global, taking place in Paris, France.