INCI page

ADENOSINE

Last update on Jul 2, 2026

Adenosine is a naturally occurring nucleoside composed of adenine and ribose. In cosmetics, it is valued for its ability to improve skin firmness, reduce the appearance of wrinkles, and support cellular energy metabolism. It helps stimulate collagen production and enhance skin elasticity. This powerful anti-aging active is commonly used in premium serums, creams, eye treatments, and masks targeting mature or tired-looking skin.

CAS Number: 58-61-7Chem/IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolEINECS/ELINCS No: 200-389-9COSING REF No: 31367

Products with ADENOSINE

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SHINE+ Reju M-AT

by Uniproma Chemical

INCI: ADENOSINE | TARTARIC ACID

Original documents

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Adenosine-97

by Biogenics

INCI: PENTYLENE GLYCOL | ADENOSINE | NIACINAMIDE | TOCOPHEROL | DIPROPYLENE GLYCOL

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Actera Adenosine™

by Actera Ingredients

INCI: ADENOSINE

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What is ADENOSINE used for?

Skin conditioning & anti-aging: Helps reduce fine lines and wrinkles while improving firmness and elasticity. Frequently used in anti-aging serums and creams.
Energizing skin cells: Supports cellular energy (ATP) production for healthier, more resilient skin. Ideal for revitalizing and firming formulations.
Soothing & barrier support: Contributes to overall skin health and calmness. Common in eye creams and sensitive skin products.

Origin

Adenosine is naturally present in the human body and can be derived from yeast fermentation or produced synthetically. In cosmetics, it is typically obtained through bio-fermentation or chemical synthesis to ensure high purity and stability. It is supplied as a white crystalline powder and is water-soluble.

What does ADENOSINE do in a formulation?

SKIN CONDITIONING|

SOOTHING

Safety Profile

Adenosine is considered safe for cosmetic use with a low hazard rating from EWG (1). The CIR Expert Panel has assessed it as safe as used. It is non-irritating and well-tolerated across skin types, including sensitive skin. Approved by the EU COSING database for skin conditioning functions in leave-on products.