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PALMITOYL TRIPEPTIDE-5

Last update on May 26, 2026

Palmitoyl Tripeptide-5 is a synthetic lipo-peptide consisting of a palmitic acid chain attached to the amino acid sequence Lys-Val-Lys. It is a well-known anti-aging active designed to stimulate collagen synthesis, improve skin firmness, and reduce the appearance of wrinkles. The lipid chain enhances skin penetration, making it more effective than non-lipidated peptides. It is widely used in premium anti-aging serums, creams, eye treatments, and firming products.

CAS Number: 623172-56-5Chem/IUPAC Name: Palmitoyl Tripeptide-5 EINECS/ELINCS No: COSING REF No: 56920

Products with PALMITOYL TRIPEPTIDE-5

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SHINE+ Elastomeptide

by Uniproma Chemical

INCI: PALMITOYL TRIPEPTIDE-5 | HEXAPEPTIDE-11 | HEXAPEPTIDE-9 | GLYCERIN | AQUA

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ActiTide® Bouncera

by Uniproma Chemical

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EyeComplex 4

by MakingCosmetics

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What is PALMITOYL TRIPEPTIDE-5 used for?

Skin conditioning & firming: Stimulates collagen production and improves skin elasticity. Frequently used in anti-aging creams and serums to reduce fine lines and wrinkles.
Anti-aging: Helps restore skin firmness and smoothness. Ideal for mature skin and targeted wrinkle treatments.
Barrier support: Supports the skin’s structural integrity. Common in firming lotions and neck creams.

Origin

Palmitoyl Tripeptide-5 is produced synthetically using solid-phase peptide synthesis. The tripeptide (Lys-Val-Lys) is assembled and then conjugated with palmitic acid. This biomimetic peptide is designed to mimic natural signaling molecules in the skin for improved efficacy and penetration.

What does PALMITOYL TRIPEPTIDE-5 do in a formulation?

SKIN CONDITIONING

Safety Profile

Palmitoyl Tripeptide-5 is considered safe for cosmetic use with a low hazard rating from EWG (1). It is non-irritating, non-sensitizing, and well-tolerated across skin types, including sensitive skin. Its large molecular size limits systemic absorption. Approved by the EU COSING database for skin conditioning functions in leave-on products.