New active ingredient from blue biotechnology to address inflamm’aging by Seppic
Last update on May 27, 2026
Addressing the growing “well-aging” and “skin longevity” trends, Seppic drew inspiration from the marine world to develop MACRO’AGE™.
According to the company, the ingredient is designed to support the skin’s natural recovery, addressing the inflamm'aging phenomenon (superficial chronic inflammation) which degrades the skin barrier and extracellular matrix over time, leading to visible signs of skin aging.
View Seppic's full product range directly in the Master Catalog of Cosmetics
Dual-action on inflammation mediators and skin structure
Seppic produces MACRO’AGE™ using its Celebrity™ biotechnology platform, which cultivates macroalgae in bioreactors. According to Seppic, the active ingredient is derived from a microscopic form of the Macrocystis pyrifera algae, enabling access to specific active molecules that would otherwise remain inaccessible through conventional processes.
According to Seppic, MACRO’AGE™ supports mature skin through a dual action on inflammation mediators and skin structure:
Inhibits pro-inflammatory mediator LTB4 while stimulating and protecting specialized pro-resolving mediators (SPMs) such as Resolvins and Maresins (ex vivo).
- Improves skin architecture (in vitro and ex vivo) by stimulating the synthesis of Collagen I and Hyaluronic Acid, with reported efficacy to retinol , an ingredient known for its properties in skin renewal. MACRO’AGE™ helps protect Collagen I and Claudin-1 proteins from inflammation-induced degradation.
Clinically tested at 1%, MACRO’AGE™ demonstrated efficacy in supporting healthy aging.
Anti-aging agents: How to select the right grade for cosmetics? >> Decode here >>
After 56 days, the ingredient improved mature skin smoothness by more than 7¤¤ times and tonicity by 3¤ times vs. bakuchiol, while also enhancing complexion appearance, Seppic reported. Within 14 days, it also strengthens skin architecture, improving skin elasticity by 10%* versus placebo, supporting fast-acting efficacy claims.
Seppic stated that MACRO’AGE™ is COSMOS- and Nature-approved and contains 100% natural-origin content according to ISO 16128 guidelines. The ingredient is also Halal-certified, suitable for vegan formulations, and compliant with Chinese regulations, including IECSC and IECIC.
Seeking anti-aging agents from Seppic? See grades here!
Mélodie COUVRAT, product manager beauty care at Seppic, said, “With MACRO’AGE™, we are targeting a new approach to skin longevity that focuses on skin inflammation resolution. Through our Celebrity™ blue biotechnology, we unlocked the hidden power of a rare alga form to offer proven higher-performance vs. placebo, bakuchiol & retinol.”
¤¤p<0.01 vs. bakuchiol
¤p<0.05 vs. bakuchiol
*p<0.05 vs. placebo