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POLYGONUM CUSPIDATUM ROOT EXTRACT

Last update on Mar 20, 2026

Polygonum Cuspidatum Root Extract is commonly known as Japanese knotweed root extract. It is a powerful botanical rich in trans-resveratrol (the primary active), emodin, polydatin, quercetin, piceid, and other polyphenols. It is one of the highest natural sources of resveratrol and is prized for its exceptional antioxidant, anti-aging, anti-inflammatory, brightening, and skin-protective properties. This light to medium brown liquid or powder is widely used in premium anti-aging serums, brightening treatments, protective day creams, sunscreens, and soothing masks. It is commonly included in formulations targeting photoaging, hyperpigmentation, redness, and loss of firmness.

CAS Number: 501-36-0Chem/IUPAC Name: Polygonum Cuspidatum Root ExtractEINECS/ELINCS No: COSING REF No: 58652

Products with POLYGONUM CUSPIDATUM ROOT EXTRACT

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MultiEx BSASM™

by Biospectrum

INCI: CHAMOMILLA RECUTITA FLOWER EXTRACT | CENTELLA ASIATICA EXTRACT | GLYCYRRHIZA GLABRA ROOT EXTRACT | CAMELLIA SINENSIS LEAF EXTRACT | POLYGONUM CUSPIDATUM ROOT EXTRACT | ROSMARINUS OFFICINALIS LEAF EXTRACT | SCUTELLARIA BAICALENSIS EXTRACT | BUTYLENE GLYCOL | AQUA
  • Sustainable option

Knotweed root extract

by Dermalab

INCI: POLYGONUM CUSPIDATUM ROOT EXTRACT
  • Sustainable option

RESVERATROL BT

by Bio Component Research

INCI: POLYGONUM CUSPIDATUM ROOT EXTRACT | AQUA
  • Sustainable option

What is POLYGONUM CUSPIDATUM ROOT EXTRACT used for?

  • Antioxidant protection: Extremely potent free-radical scavenger (resveratrol is often compared to or synergistic with vitamin C/E). Frequently used in day creams, serums, and sunscreens for prevention of photoaging, oxidative stress, and environmental damage.
  • Anti-aging / Firming: Boosts collagen synthesis, inhibits MMPs (matrix metalloproteinases), and improves elasticity. Ideal for mature skin products, neck/firming creams, and anti-wrinkle treatments.
  • Brightening / Tone evening: Inhibits tyrosinase and melanin transfer, reduces hyperpigmentation. Common in spot correctors, brightening serums, and even-tone formulations.
  • Soothing & anti-inflammatory: Calms irritation, redness, and inflammation. Used in sensitive skin lines, rosacea care, after-sun products, and post-procedure treatments for comfort and barrier support.

Origin

Polygonum Cuspidatum Root Extract is sourced from the roots of Japanese knotweed (Polygonum cuspidatum / Fallopia japonica), a perennial plant native to East Asia (China, Japan, Korea) and now widespread globally. Roots are harvested, cleaned, dried, and extracted using water, glycerin, ethanol, or supercritical CO₂ to concentrate resveratrol (typically 50-98% in standardized grades), polydatin, emodin, and other polyphenols. This sustainable process yields a high-potency extract suitable for clean, vegan, and natural cosmetic formulations.

What does POLYGONUM CUSPIDATUM ROOT EXTRACT do in a formulation?

ANTIOXIDANT|
SKIN PROTECTING|
SOOTHING

Safety Profile

Polygonum Cuspidatum Root Extract is considered safe for cosmetic use. It has a very low hazard rating from EWG (typically 1) and minimal concerns for irritation, sensitization, or toxicity at typical concentrations (0.1-5%; often effective at 0.5-2% for resveratrol-standardized grades). It is well-tolerated across skin types, including sensitive and acne-prone, with strong antioxidant and soothing properties. Rare allergic reactions may occur in those sensitive to Polygonaceae family plants. Patch testing is recommended. High-resveratrol extracts are generally non-irritating.

POLYGONUM CUSPIDATUM ROOT EXTRACT alternatives

POLYGONUM CUSPIDATUM ROOT EXTRACT technical profile

PropertyValues
pH4.0 - 7.0
SolubilitySoluble in water/glycols (aqueous extract) or oils
ViscosityLow

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