Givaudan unveils biotechnology-derived hyaluronic acid to activate skin renewal
Last update on Apr 15, 2026
Givaudan Active Beauty has been working on the science behind hyaluronic acid for years. Building on this, PrimalHyal™ 300, a medium molecular weight hyaluronic acid derived from biotechnology, acts as the ‘healer’ of the PrimalHyal™ range and represents a go-to active ingredient for fast skin recovery and repair.
Designed as the skin healing accelerator, PrimalHyal™ 300 strengthens the skin’s natural defense system and helps accelerate recovery when the barrier is compromised, particularly in post-procedure care.
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Restores skin barrier strength in just a few days
Developed in the Champagne region of France through sustainable innovation, PrimalHyal™ 300 is produced in a biorefinery rooted in the principles of the circular economy, reflecting Givaudan Active Beauty’s commitment to responsible innovation and performance-driven skin science.
With aesthetic treatments having increased fivefold over the last 30 years1, understanding and supporting this mechanism has never been more critical. Recent scientific discoveries2 have highlighted bleomycin hydrolase as a key enzyme involved in hydration, wound healing, and epidermal barrier integrity. When the skin barrier is disrupted, fast and coordinated repair becomes essential.
PrimalHyal™ 300 activates skin renewal by boosting bleomycin hydrolase levels by 79%, helping the skin remain hydrated while accelerating its natural recovery.
In ex vivo explant models, even after harsh chemical peeling, PrimalHyal™ 300 helped restore skin barrier strength in just a few days and significantly increased ceramide content (up to 15-fold versus control) – the natural ‘cement’ that binds skin cells together.
These effects were confirmed by clinical studies conducted on women who underwent deep fractional CO2 laser treatments:
- After three days: visible improvement in hydration
- After one week: substantial reduction in redness and irritation
- Overall: smoother, calmer and more resilient skin
“Our skin is our first line of defence – a complex and dynamic structure that must repair itself effectively when compromised. PrimalHyal™ 300 is the result of years of research into how hyaluronic acid can support the skin’s natural repair and cell reconnection processes. By specifically reactivating bleomycin hydrolase production, it helps the skin heal better, faster and more effectively,” said Amandine Scandolera, head of Biological Evaluation at Givaudan Active Beauty.
As aesthetic treatments continue to rise in popularity, PrimalHyal™ 300 represents a science-backed breakthrough in skin regeneration, offering a new era in skin hydration, accelerated recovery and skin barrier restoration.
To learn more about their new ingredient and its inspirational concept, S3D® SkinXpert, the company invites you to visit us on 14-16 April 2026 at booth #3F110, 3F130 at in-cosmetics Global, taking place in Paris, France.
1 - Noël B., Dermatologie esthétique et correctrice : applications cliniques et rôle social, Revue Médicale Suisse, 2009. DOI: 10.53738/REVMED.2009.5.200.0895.
2 - Riise, R., Odqvist, L., Mattsson, J. et al. Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes. Sci Rep 9, 20407 (2019).