INCI page

TRICLOSAN

Last update on Dec 18, 2025

Triclosan is a synthetic broad-spectrum antimicrobial agent historically used in cosmetics as a preservative and deodorant component. It effectively inhibits bacterial growth and helps control odors in products like toothpastes, deodorants, soaps and mouthwashes. Due to regulatory updates addressing potential endocrine concerns, its use is now significantly restricted in many regions. Formulators are shifting toward safer alternatives while legacy products phase out.

CAS Number: 3380-34-5Chem/IUPAC Name: 5-Chloro-2-(2,4-dichlorophenoxy)phenolEINECS/ELINCS No: 222-182-2COSING REF No: 38663

What is TRICLOSAN used for?

  • Preservative: Inhibits microbial growth to extend shelf life. Historically applied in rinse-off products like hand soaps and shower gels.
  • Antimicrobial/Deodorant: Reduces odor-causing bacteria on skin. Common in non-spray deodorants and foot care items.
  • Oral care support: Helps control plaque and gingivitis in toothpastes. Now limited with age restrictions and warnings.
  • Masking: Neutralizes unpleasant odors from raw materials. Occasionally used in deodorants and body care formulations.

Origin

Triclosan is produced synthetically by condensing 2,4-dichlorophenol with potassium hydroxide and 2,4,5-trichloronitrobenzene, followed by reduction and purification. This petrochemical-derived process yields a high-purity white crystalline powder with consistent antimicrobial activity for industrial applications.

What does TRICLOSAN do in a formulation?

DEODORANT|
PRESERVATIVE|
ANTIMICROBIAL|
MASKING

Safety Profile

Triclosan has been evaluated for potential endocrine disruption and environmental persistence. Per EU Regulation 2024/996 (based on SCCS/1643/22), aggregate exposure risks led to tightened restrictions: prohibited in mouthwashes, banned in toothpastes for children under 3 years, and other use limits. Non-compliant products were phased out by 31 October 2025. It remains permitted only in specific compliant applications at low levels. Many brands have voluntarily discontinued use; consult current regional regulations for exact status.

TRICLOSAN technical profile

PropertyValues
Boiling Point280°C-290°C
Melting Point55°C-57°C
pHNeutral (pKa ~8.1)
SolubilitySlightly soluble in water; highly soluble in ethanol and oils