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SUPEROXIDE DISMUTASE

Last update on Dec 10, 2025

Superoxide Dismutase, often abbreviated as SOD, is a powerful enzyme-based antioxidant. It is widely used in cosmetics to combat oxidative stress. It neutralizes superoxide radicals, protecting skin cells from damage that leads to premature aging. This ingredient is especially valued in anti-aging serums, creams, and UV-protective formulations for its ability to reduce inflammation and support skin repair. Its role in maintaining youthful skin makes it a staple in high-performance skincare products targeting environmental stressors and free radical exposure.

CAS Number: 9054-89-1Chem/IUPAC Name: Superoxide DismutaseEINECS/ELINCS No: 232-943-0COSING REF No: 80509

Products with SUPEROXIDE DISMUTASE

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Zymo Radical

by I.R.A. Istituto Ricerche Applicate

INCI: CYCLODEXTRIN | LACTOPEROXIDASE | SUPEROXIDE DISMUTASE

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Liposystem Complex® of Superoxide Dismutase 1,000,000 IU/kg

by I.R.A. Istituto Ricerche Applicate

INCI: GLYCERIN | LECITHIN | SUPEROXIDE DISMUTASE

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REGU® -AGE CB

by DSM-Firmenich

INCI: HYDROLYZED RICE PROTEIN | GLYCINE SOJA PROTEIN | SUPEROXIDE DISMUTASE

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What is SUPEROXIDE DISMUTASE used for?

Antioxidant protection: Neutralizes superoxide radicals to prevent cellular damage. Commonly incorporated in anti-aging serums and day creams to shield against UV and pollution.
Skin conditioning: Supports skin barrier function and reduces inflammation. Found in hydrating lotions and repair masks to promote even tone and resilience.
Reducing agent: Aids in stabilizing formulations while brightening skin. Ideal for whitening creams and calming treatments targeting hyperpigmentation.

Origin

Superoxide Dismutase is primarily produced through biotechnology. It is often derived from yeast like Saccharomyces cerevisiae or bacterial sources such as E. coli. The process involves recombinant expression of the enzyme gene in host cells, followed by purification to yield a stable, active protein. This method ensures high potency and consistency, making it suitable for cosmetic applications where natural enzyme activity is essential for efficacy.

What does SUPEROXIDE DISMUTASE do in a formulation?

ANTIOXIDANT|

REDUCING|

SKIN CONDITIONING

Safety Profile

Superoxide Dismutase is considered safe for topical cosmetic use and receives a low hazard rating from EWG, with minimal concerns for irritation or sensitization at typical levels of 0.1 to 1%. It is generally well-tolerated across skin types and is approved under global regulatory frameworks. As an enzyme, it presents a low risk of systemic effects, though patch testing is recommended for sensitive individuals. The EU COSING database also supports its use in leave-on products for skin-conditioning and antioxidant functions.