INCI page

METHYL DIISOPROPYL PROPIONAMIDE

Last update on May 15, 2026

Methyl Diisopropyl Propionamide is a synthetic cooling agent known for providing a long-lasting, fresh cooling sensation on the skin and mucous membranes. Unlike menthol, it delivers a clean, non-minty cooling effect with minimal odor and low volatility. It is widely used in skincare, oral care, deodorants, after-sun products, and hair care to give a refreshing, soothing, and tingling sensation without irritation.

CAS Number: 51115-67-4Chem/IUPAC Name: Butanamide, N,2,3-trimethyl-2-(1-methylethyl)-EINECS/ELINCS No: 256-974-4COSING REF No: 78259

Products with METHYL DIISOPROPYL PROPIONAMIDE

See all products

With samples available

Symcool® WS-23

by Symrise

INCI: METHYL DIISOPROPYL PROPIONAMIDE

See the product

HydroSal® FreshCool

by Salvona Technologies

See the product

Fresh’in Green+

by Minasolve

INCI: PENTYLENE GLYCOL | METHYL DIISOPROPYL PROPIONAMIDE

Sustainable option

See the product

What is METHYL DIISOPROPYL PROPIONAMIDE used for?

Cooling agent: Provides a prolonged cooling and refreshing sensation. Frequently used in after-sun gels, moisturizers, and body lotions.
Skin conditioning: Enhances the sensory experience and gives a soothing feel. Common in toothpastes, mouthwashes, and deodorants.
Sensory enhancer: Improves product perception by adding a cooling tingle. Ideal for “icy” or refreshing cosmetic lines.

Origin

Methyl Diisopropyl Propionamide is produced synthetically through the reaction of diisopropylamine with an appropriate acid chloride or anhydride. It is a high-purity synthetic cooling agent engineered to be more stable and less irritating than natural menthol.

What does METHYL DIISOPROPYL PROPIONAMIDE do in a formulation?

MASKING|

SKIN CONDITIONING

Safety Profile

Methyl Diisopropyl Propionamide is considered safe for cosmetic use at typical concentrations (0.1-1.0%). It has a low hazard rating and is generally well-tolerated. It is less irritating to the skin and eyes than menthol. Approved by the EU COSING database for skin conditioning and refreshing functions in rinse-off and leave-on products.