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HELIOTROPINE

Last update on Apr 22, 2026

Heliotropine, also known as piperonal, is a synthetic aromatic compound widely used in cosmetic fragrance formulations. It is characterized by its sweet, floral scent reminiscent of heliotrope flowers, vanilla, and almond-like nuances, making it a common fragrance modifier in perfumes, skincare, and personal care products. In cosmetic systems, heliotropine is primarily used as a fragrance ingredient and masking agent to enhance olfactory profiles of formulations such as creams, lotions, shampoos, and deodorants. It may also be found in fine fragrance compositions and scented personal care products where soft floral notes are desired.

CAS Number: 120-57-0Chem/IUPAC Name: 1,3-Benzodioxole-5-carboxaldehydeEINECS/ELINCS No: 204-409-7COSING REF No: 34245

Products with HELIOTROPINE

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Heliotropin

by UBE

INCI: HELIOTROPINE | PARFUM

Vanilla Fragrance Oil

by New Directions Aromatics

INCI: ETHYL VANILLIN | COUMARIN | BENZYL BENZOATE | HELIOTROPINE | VANILLIN
  • Sustainable option

Butter Cream Icing Fragrance Oil

by New Directions Aromatics

INCI: ETHYL HYDROXYPYRONE | HELIOTROPINE | COUMARIN | MYROXYLON BALSAMUM PEREIRAE BALSAM OIL | ETHYL VANILLIN
  • Sustainable option

What is HELIOTROPINE used for?

Heliotropine is valued mainly for its fragrance and sensory-enhancing properties in cosmetic and personal care formulations. 

  • Fragrance ingredient: Contributes sweet, powdery floral notes in perfumes, body lotions, and hair care products, often used to build heliotrope, vanilla, or almond scent profiles.
  • Odor masking agent: Helps mask unpleasant base odors in formulations such as actives, emulsifiers, and botanical extracts.
  • Perfume modifier: Blends well with aldehydes, vanillin derivatives, and floral accords to round off sharp fragrance edges.
  • Sensory enhancement: Improves perceived product elegance in leave-on and rinse-off formulations like creams, cleansers, and deodorants.

Origin

Heliotropine is primarily obtained through synthetic processes in the fragrance industry. It is commonly produced via oxidation of safrole or isosafrole derivatives, ensuring controlled purity and consistency suitable for cosmetic applications. Historically, it was also associated with natural extraction routes from certain plant sources containing safrole-like compounds, but modern cosmetic-grade heliotropine is predominantly synthetically manufactured to meet regulatory and safety standards. The compound is then purified and incorporated into fragrance blends or supplied as a raw aromatic ingredient for perfumery and cosmetic formulation use.

What does HELIOTROPINE do in a formulation?

MASKING|
SKIN CONDITIONING|
PERFUMING

Safety Profile

Heliotropine is widely used in cosmetics at low concentrations, primarily as a fragrance component. It is generally considered safe for use within regulatory limits defined by IFRA (International Fragrance Association) standards. 

However, as with many fragrance substances, it may pose sensitization risks in sensitive individuals when used at higher concentrations. It is therefore typically included in formulations at controlled levels.

  • Approved for use as a fragrance ingredient in cosmetics
  • Use levels are restricted in leave-on products based on IFRA guidance
  • May cause skin sensitization in susceptible individuals (rare cases)
  • Recommended to be used with proper formulation control in sensitive skin products

HELIOTROPINE alternatives

HELIOTROPINE technical profile

PropertyValues
Boiling Point~263-265°C
Melting Point~36-40°C
SolubilitySlightly soluble in water; soluble in alcohols and oils
ViscosityLow to moderate

Formulations with HELIOTROPINE

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By Application

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