Benzisothiazolinone is used in cosmetics as a preservative and biocide. It exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and yeast, making it effective in various formulations, particularly those that are water-based. It also stabilizes formulations by preventing the degradation of active ingredients. In its raw form, Benzisothiazolinone appears as a white to off-white crystalline powder with a subtle aromatic odor that is not overpowering in formulations. It is commonly found in products like moisturizers, shampoos, makeup products, and sunscreens. The chemical formula of Benzisothiazolinone is C7H5NOS.
CAS Number: 2634-33-5Chem/IUPAC Name: 1,2-Benzisothiazol-3(2H)-oneEINECS/ELINCS No: 220-120-9COSING REF No: 32133Products with BENZISOTHIAZOLINONE
With samples available
EBTcare BIT-85
by Quzhou Ebright Chemicals
Microcare® SI
by Thor
PROCARE™ 505
by Shuangyou
What is BENZISOTHIAZOLINONE used for?
Benzisothiazolinone is a potent preservative and antimicrobial agent used in cosmetics. It effectively prevents the growth of bacteria, fungi, and yeast, ensuring product safety and extending shelf life. Commonly found in moisturizers, shampoos, conditioners, and makeup products, it helps maintain the integrity of formulations by stabilizing active ingredients against microbial contamination. Additionally, Benzisothiazolinone is often included in wet wipes and cleansing products for its preservation properties.
Origin
Benzisothiazolinone is synthesized through the reaction of 2-mercaptobenzothiazole with sodium hydroxide and chloroacetyl chloride. In this process, the mercaptobenzothiazole is first deprotonated, creating a nucleophilic species that reacts with chloroacetyl chloride, forming the isothiazolinone structure. The resulting product is then purified, often through recrystallization or distillation, to ensure a high level of purity suitable for use in cosmetic formulations.
What does BENZISOTHIAZOLINONE do in a formulation?
ANTIMICROBIAL|
PRESERVATIVE|
STABILISINGSafety Profile
Benzisothiazolinone is typically considered safe when used in cosmetic formulations at concentrations ranging from 0.01% to 0.1%. Higher concentrations have been linked to potential skin sensitization and allergic reactions. Regulatory bodies, including the Cosmetic Ingredient Review (CIR) and the European Union, have established guidelines for its safe use, limiting concentrations to minimize risks. In any case, a patch test is recommended prior to full application.
BENZISOTHIAZOLINONE alternatives
BENZISOTHIAZOLINONE technical profile
| Property | Values |
| Melting Point | 158°C |
| pH | 5-7 |
| Solubility | Soluble in water and organic solvents |
| Viscosity | Low |
Formulations with BENZISOTHIAZOLINONE
No data available
By Application
No data available