Uniproma's recombinant humanized elastin: Your go-to solution for anti-aging issues

Elastin plays an irreplaceable role in maintaining skin elasticity, firmness, and a youthful appearance. With age, the body's ability to synthesize elastin gradually declines. Coupled with damage from external factors (e.g., UV radiation, pollution) and unhealthy lifestyle habits (e.g., sleep deprivation, smoking), elastin loss accelerates, leading to visible signs of aging such as sagging, increased fine lines, loss of skin firmness, and a blurred, less defined facial contour.

 

Recombinant Humanized Elastin provides essential mechanical support to skin tissue by offering mechanical stimulation and responding to mechanical stretching, counteracting skin laxity and deformation caused by gravity. As a molecular target that directly improves skin elasticity and toughness, elastin can enhance the structural integrity of skin and reduce wrinkle formation. From a long-term sustainability perspective, recombinant humanized elastin also stimulates fibroblast activity, promoting the skin's own collagen and elastin synthesis to delay skin aging. Direct elastin supplementation can make skin softer and smoother, improving overall texture.

 

The unique β-spiral "spring-like" structure serves as the structural foundation for the elasticity and toughness of recombinant humanized elastin. As the pioneer in recombinant humanized elastin, Advanced Regenerative Medicine Technology Co., Ltd. has established industry benchmarks through seven proprietary cutting-edge technologies, breaking through technical barriers in the field. 

Utilizing secondary structure folding technology, the company has successfully prepared elastin with characteristic β-spiral structures, achieving precise biomimicry of natural elastin. This breakthrough ingredient can further assemble into highly flexible layered elastic fibers, mimicking the resilience and pliability of natural elastic fibers. By directly replenishing elastin, it provides instant lifting and firming effects, restoring skin elasticity.

 

Elastin's unique hydrophilic/hydrophobic block structure provides distinct advantages in conferring tissue elasticity, stability, and tensile strength, as well as in tissue engineering and biomaterial applications. 
 

• Hydrophobic domains (GVGVP, GGVP, and GVAP) promote the aggregation of elastin chains, endowing elastin with elastic properties.
• The hydrophilic domains form cross-linked structures such as desmosine and isodesmosine, providing elastin with durable elasticity and toughness.

The hydrophilic/hydrophobic block structure enables elastin to form a complex cross-linked network that enhances the skin's mechanical strength and toughness. This structure allows the skin to withstand repeated stretching and compression without damage, maintaining elasticity and function in various environments.

 

Advanced Regenerative Medicine has formed a top-level scientific research team and established a complete R&D chain spanning basic research to product development.

Through eight years of technological research from molecular structure analysis to functional mechanism exploration, we have established high technical barriers in the industry. We have overcome the current technical limitations of recombinant elastin, such as a lack of secondary structure, poor water solubility, low expression levels, difficulties in industrialization, and challenges in skin penetration. 

This achievement represents an outstanding transformation from laboratory to production line, making us the first to achieve mass production of high-quality medical-grade recombinant humanized elastin.

 

Today, through seven core technologies: 100% humanized elastin rational design technology, secondary structure folding technology, soluble high expression fermentation technology, specific enzymatic purification technology, endotoxin removal technology, ADI multi-dimensional transdermal technology, and elastin signaling network integration, recombinant humanized elastin has emerged as the world's first new-generation anti-aging 'top performer.' 

It closely biomimics the natural human β-spiral secondary structure and achieves 100% sequence identity. The material effectively replicates the biological functions of natural elastin. It also maintains endotoxin levels below 0.01 EU/ml and reaches 98% purity.

Example 1: 100% humanized elastin rational design technology. The functional sequence of recombinant elastin is 100% derived from human elastin, featuring biomimetic continuous hydrophilic/hydrophobic alternating domains that form natural elastin-like secondary structures. It interacts effectively with key functional proteins such as integrins and elastin-binding proteins (EBP).

 

Example 2: Secondary Structure Folding Technology. The β-spiral secondary structure is the most critical structural feature for elastin functionality, as elastin without a β-spiral structure exhibits no bioactivity. Currently, all competing products contain only primary sequences without well-formed secondary structures. Advanced Regenerative Medicine has successfully developed a β-spiral "spring-like" structure containing biomimetic functional domains of natural elastin. Circular dichroism is the gold standard for analyzing protein secondary structure. Recombinant humanized elastin exhibits circular dichroism spectral characteristics similar to those of natural elastin, demonstrating its excellent elasticity.

 

In addition, Advanced Regenerative Medicine employs specific enzyme cleavage and purification technology to precisely identify and remove inactive fragments, non-human tags, and other impurities, ensuring both the purity and functionality of recombinant elastin. With 98% purity, our recombinant humanized elastin remains the world's only elastin product meeting medical implant-grade purity standards. 

 

It is widely recognized that endotoxins exhibit remarkable stability and require extremely stringent conditions for removal. Leveraging the unique properties of recombinant elastin, Advanced Regenerative Medicine has developed an endotoxin removal technology that effectively eliminates endotoxin residues from recombinant elastin, lowering endotoxin levels to significantly below the 0.5 EU/mL threshold stipulated by the medical industry standard (YY 0954-2015).

 

The recombinant humanized elastin achieves efficient transdermal absorption through proprietary ADI Multi-Dimensional Transdermal Technology, with high penetration efficiency reaching all layers of the dermis. After a single application of 1000 ppm recombinant humanized elastin, fluorescence microscopy within 1 hour shows significant green fluorescence in both epidermis and dermis. The transdermal rate reaches 90%, demonstrating effective transdermal absorption and the ability to penetrate deep into skin layers to directly replenish elastin.

 

Recombinant humanized elastin exhibits exceptional structural stability through its unique β-spiral secondary structure. This stability enables it to resist environmental disturbances (such as temperature and pH fluctuations) while maintaining activity in complex formulations. It meets diverse product requirements and demonstrates excellent compatibility in formulated products.

 

Recombinant humanized elastin remains highly stable in formulations, preventing denaturation or degradation to ensure long-term preservation of its bioactivity. This characteristic makes elastin an "all-round performer" in anti-aging products, suitable for various formulations including serums, creams, and masks. This significantly simplifies formulation development while ensuring the efficacy and quality of the products, providing consumers with long-lasting and noticeable anti-aging effects.

 

Through testing and analyzing various recombinant humanized elastin formulations at different temperatures and time durations, and observing and identifying various physical and chemical indicators such as appearance and activity, it was confirmed that recombinant humanized elastin showed long-term stability in different formulations.

Recombinant humanized elastin has both instant and long-lasting effects, making it a key ingredient in the anti-aging field. After rigorous human testing, recombinant humanized elastin has demonstrated remarkable efficacy in reducing signs of aging. The unique molecular structure of recombinant humanized elastin can quickly penetrate deep into the skin, bind to the skin's own elastic fibers, immediately smooth out wrinkles and fine lines, and restore the skin's fullness and elasticity. This instant effect allows users to see and feel visible improvements.

 

Long-term use of recombinant humanized elastin can effectively strengthen the skin barrier, reduce water loss, continuously improve skin firmness and elasticity. It also helps diminish the appearance of wrinkles, keeping the skin healthy and youthful. Its excellent moisturizing, anti-wrinkle and repairing establish it as a key ingredient in anti-aging skincare.


 

Skin stratum corneum moisture:

Note: The 14 d measurement values are compared with the baseline values. 
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects exhibited a 14.74% increase in stratum corneum moisture content compared to baseline measurements.


 

Skin Wrinkle (SEw) value:

Note: The 14 d measurement values are compared with the baseline values. 
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects demonstrated a 15.20% reduction in skin wrinkle (SEw) values compared to baseline measurements.


 

Facial redness area:

Note: The 14 d measurement values are compared with the baseline values. 
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects exhibited a 26.85% reduction in facial redness compared to baseline measurements.


 

Trans-Epidermal Water Loss (TEWL):

Note: The 14 d measurement values are compared with the baseline values. 
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects demonstrated an 11.61% reduction in facial transepidermal water loss (TEWL) values compared to baseline measurements.


 

Skin firmness characteristic value F4:

Note: The 14 d measurement values are compared with the baseline values.
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects demonstrated a 16.37% increase in facial skin firmness (F4) compared to baseline measurements.


 

Skin elasticity characteristic value R2:

Note: The 14 d measurement values are compared with the baseline values.
 

• "ns" indicates no significant difference;
• "*" indicates a significant difference with 0.01 ≤ p
• "**" indicates a significant difference with 0.001 ≤ p
• "***" indicates a significant difference with p

After 14 days of using the test product, subjects exhibited a 17.48% increase in skin elasticity (R2) compared to baseline measurements.


 

28-day comprehensive skin parameter change rate:

In the functional skincare field, recombinant humanized elastin is acclaimed as a "safe, painless skincare alternative to Thermage" and serves as an ideal anti-aging ingredient. In medical device applications, it excels in wound repair. As a biological hemostatic material, it requires no secondary removal and enables scar-free healing. In the field of aesthetic medicine, it is used in dermal implants and injectable treatments for "non-surgical thread lift" facial contouring and enhanced skin texture.
 

 

Recombinant humanized elastin: the anti-aging "superstar" breaking all boundaries. Engineered with a unique β-spiral secondary structure, recombinant humanized elastin delivers unparalleled anti-aging effects, reshaping the future of skincare.

From its exceptional structural stability and formulation advantages to the high-tech barriers in R&D and production, recombinant humanized elastin has demonstrated unmatched potential in the functional skincare market. More than just a product, it represents a scientific revolution in beauty and wellness.

With over 20 years of deep expertise in the cosmetic ingredients industry, Uniproma has been committed to introducing cutting-edge innovations to meet the growing demand for more effective, greener, and sustainable solutions. Backed by our extensive experience in high-performance cosmetic ingredients and a well-established global supply chain, we partner with our clients to bridge science and nature, shaping a better world together.


Connect with us: info@uniproma.com | www.uniproma.com
 

DISCLAIMER: All figures, tables, and graphs used in this article are copyright of Uniproma Chemical.